Flexible Retro t Design of Multiproduct Batch Plants R Related Information

Participative Bureaucracy and Productivity in the Machined

Jul 01, 1996 · After taking into account the quality and complexity of the product and controls for i n d ~ s t r yI, ~ expect three types of variables to influence the efficiency with which machining operations are performed: work organization attributes, the technology and operations strategy of the enterprise for the machining process at the plant, and

"Design and scheduling of multiproduct batch plants with

In many segments of the chemical industry, emphasis is nowadays placed upon meeting customer needs. This imposes new requirements in terms of various product quality specifications as well as due dates for deliveries, and provides an important incentive for the development of comprehensive procedures for the design and scheduling of multiproduct batch processes.

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Design, synthesis and scheduling of multipurpose batch

optimal design of sequential multiproduct batch pro-cesses as a mixed-integer nonlinear programming (MINLP) problem. On this basis, Suhami and Mah (1982) studied the optimal design of multipurpose batch plant focusing on a restricted form of the problem …

(PDF) Pharmaceutical Process Validation | joan gonzalez

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Improving Material Efficiency for Ultra-efficient

Jan 01, 2016 · Grundemann, Laura, Vera Gonschorowski, Norbert Fischer, and Stephan Scholl. Cleaning Waste Minimization for Multiproduct Plants: Transferring Macro Batch to Micro Conti Manufacturing. Journal of Cleaner Production 2012; 24. P. 92-101. [22] Minner S, and G. Kiesmueller: Dynamic Product Acquisition in Closed- Loop Supply Chains.

[PDF] Wastewater minimisation using central reusable water

This paper presents a continuous-time mathematical formulation for freshwater and wastewater minimisation in multipurpose batch plants with and without a central reusable water storage facility. The minimisation of wastewater is achieved through the exploitation of recycle and reuse opportunities. A superstructure that entails all the possible recycle and reuse possibilities is used as the

Flexibility, reliability and maintenance considerations in

Jan 01, 1996 · A multiproduct batch plant design model is used throughout the text to illustrate the concepts (for ease in the presentation). BATCH PLANT DESIGN AND FLEXIBILITY-RELIABILITY OPTIMIZATION Consider a simplified multiproduct batch plant design model involving N products, operating in single cam- paign without intermediate storage, in M stages

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Design and operation of multiproduct and multipurpose

Jan 01, 1983 · Design and operation of multiproduct and multipurpose batch chemical plants 481 Wiede, W. Jr., N.C. Yeh and G.V. Reklaitis (1981). Discrete variable optimization strategies for the design of multi-product processes.

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Optimal design of multi-purpose batch chemical plants

Apr 01, 1989 · A review and future prospects of optimal design and operation has been published by Rippin (1983). Batch chemical plants can be classified into two classes: multiproduct and multi-purpose. In a multiproduct plant all products follow the same operation path …

Production Scheduling of a Large-Scale Industrial Batch

May 28, 2006 · The medium-term production scheduling of a multipurpose, multiproduct industrial batch plant is modeled using a novel mathematical framework. The methodology consists of the decomposition of the whole scheduling period into successive short horizons of a few days. A decomposition model is implemented to determine each short horizon and the corresponding …

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Chapter 11: Impacts on Engineering Research and Technology

The corresponding mathematical model was used to optimize the production sequence of different product lots in multiproduct batch-processing plants. A major accomplishment of this work was that problems with up to 7,000 lots could be solved to the optimal point in less than 20 minutes of computation time.

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Flexible Facility Design for Multiple Cell Therapy

Sep 29, 2021 · In many critical ways, the design of facilities for multiple cell therapy processes is unlike the design of conventional pharmaceutical facilities. This article surveys several of the key issues to consider when designing facilities capable of manufacturing multiple cell therapies, including regulatory definitions, product life cycles, processing systems, relevant cell therapy technologies and

New Continuous-Time MILP Model for the Short-Term

Oct 19, 2005 · This paper presents a new multiple-time-grid, continuous-time mixed-integer linear program (MILP) model for the short-term scheduling of multistage, multiproduct plants. It can handle both release and due dates and different objective functions efficiently, such as the minimization of total cost, total earliness, or makespan. This formulation is compared to other existing mixed-integer linear